Factors Predicting Seizure Outcome After Surgical Excision Of Meningioma : A Systematic Review

  • Alifia Firdiansari
  • Rohadi Muhammad Rosyidi
  • Bambang Priyanto
  • Surahman Hadi
  • Januarman


Abstract Background Seizures in meningiomas occur in approximately 30% of patients. Meningiomas that press on the cortical area, as well as larger meningiomas have a greater tendency to cause focal or generalized seizures. The risk of seizures is increased in tumors that grow along the surface of the brain compared to the base of the calvaria because these tumors are more often located in areas where they can compress cortical tissue that is susceptible to epileptogenesis. The study also aimed to discuss the predictors of seizure/epilepsy in post-operative patients. Methods We searched PubMed gateway database and searched the studies published between the years 2020 and 2023. The following keywords were used to search for the specific article, single and/or in combination: meningioma, seizure, epilepsy, primary brain tumor, craniotomy, predictor, and surgery. the inclusion criteria for the studies were published in English and with “human” specified as the study category. We excluded review articles, expert opinions, and other language articles. Results We included 10 studies we found that most seizures in meningioma post-operative patients are male gender, size > 8 cm, cortical location, peritumoral edema, and history of previous seizures. The occurrence of early in-hospital seizures was associated with motor cortex involvement, postoperative Karnofsky performance score <70, postoperative complications, and preoperative seizures Conclusion This systematic review shows are several predictors that can used to predict the seizure/epilepsy outcome in patients who underwent surgery for meningioma Keywords: meningioma, post-operative, seizure, epilepsy, predictors