Kadar VCAM-1 Darah Tepi dan Wilkins Score pada Stenosis Mitral Penyakit Jantung Rematik

Authors

  • Romi Ermawan Bagian Ilmu Penyakit Jantung dan Pembuluh Darah, Fakultas Kedokteran Universitas Mataram – RSUD Provinsi Nusa Tenggara Barat

Keywords:

VCAM-1, Wilkins Score, Stenosis Mitral, Penyakit Jantung Rematik

Abstract

Vascular cell adhesion molecule-1 (VCAM-1) adalah suatu protein penting dalam progresivitas kerusakan katup mitral pada penyakit jantung rematik. Untuk mengukur kerusakan katup mitral dikenal suatu sistem penilaian bernama Wilkins Score, yang terdiri atas kategori gangguan mobilitas katup, penebalan katup, kalsifikasi katup dan penebalan sub-valvular. Penelitian ini menganalisis kadar VCAM-1 darah tepi dan Wilkins Score pada penderita stenosis mitral penyakit jantung rematik. Studi analitik-observasional ini menggunakan desain cross sectional. Sampel 45 penderita stenosis mitral penyakit jantung rematik dikumpulkan secara consecutive sampling. Dilakukan pemeriksaan kadar VCAM-1 darah tepi melalui akses vena tepi, dan dilakukan pemeriksaan ekokardiografi untuk menilai Wilkins Score serta parameter terkait lainnya. Sebagai pembanding dikumpulkan juga data 22 subyek normal. Rerata Wilkins Score penderita stenosis mitral penyakit jantung rematik adalah 9,09 ± 1,81. Rerata kadar VCAM-1 darah tepi penderita dan subyek normal, yaitu 1.155,3 ± 328,8 ng/mL dan 605,5 ± 100,4 ng/mL. Terdapat perbedaan kadar VCAM-1 darah tepi yang bermakna diantara kedua kelompok (p<0,001). Didapatkan korelasi positif yang bermakna antara kadar VCAM-1 darah tepi dan gangguan mobilitas katup (p<0,001, r = +0,522), penebalan katup (p<0,001, r = +0,583), kalsifikasi katup (p<0,001, r = +0,538), penebalan sub-valvular (p<0,001, r = +0,647), dan Wilkins Score (p<0,001, r = +0,841). Terdapat korelasi positif yang bermakna antara kadar VCAM-1 darah tepi dan Wilkins Score pada stenosis mitral penyakit jantung rematik.

Published

2021-12-31

Issue

Vol. 10 No. 4 (2021): Jurnal Kedokteran

Section

Articles

License

Authors who publish with Unram Medical Journal, agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License (CC-BY License). This license allows authors to use all articles, data sets, graphics, and appendices in data mining applications, search engines, websites, blogs, and other platforms by providing an appropriate reference. The journal allows the author(s) to hold the copyright without restrictions and will retain publishing rights without restrictions.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in University of Mataram's Journal of Medicine. 
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
  4. This journal is open access journal which means that all content is freely available without charge to users or / institution. Users are allowed to read, download, copy, distribute, print, search, or link to full text articles in this journal without asking prior permission from the publisher or author.