Interaksi Protein-Protein Hormon Anti-Müllerian (AMH) dan Perannya dalam Patofisiologi Sindrom Ovarium Polikistik (PCOS): Pendekatan Bioinformatika

Penulis

  • Firda Asma'ul Husna Departemen Biologi Medis, Program Studi Kedokteran, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Sultan Ageng Tirtayasa, Kota Serang, Indonesia
  • Luluk Hermawati Departemen Biologi Medis, Program Studi Kedokteran, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Sultan Ageng Tirtayasa, Kota Serang, Indonesia
  • Nur Bebi Ulfah Irawati Departemen Parasitologi , Program Studi Kedokteran, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Sultan Ageng Tirtayasa, , Kota Serang, Indonesia
  • Hilizza Awalina Zulfa Departemen Histologi , Program Studi Kedokteran, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Sultan Ageng Tirtayasa, Kota Serang, Indonesia.
  • Ghea Farmaning Thias Putri Departemen Biologi Medis, Program Studi Kedokteran, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Sultan Ageng Tirtayasa, Kota Serang, Indonesia.
  • Yuda Nabella Prameswari Departemen Biologi Medis, Program Studi Kedokteran, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Sultan Ageng Tirtayasa, Kota Serang, Indonesia.

DOI:

https://doi.org/10.29303/jk.v14i4.8288

Kata Kunci:

AMH, PCOS, Steroidogenesis, SMAD, TGF-B

Abstrak

Abstract: A key biomarker in the context of ovarian dysfunction in PCOS is anti-Müllerian AMH. In women with PCOS, serum AMH levels are elevated 2–3-fold compared to normal women. This increase reflects changes in the expression and molecular function of AMH and its receptor (AMHR2), which may disrupt ovarian hormonal homeostasis. Although experimental studies have demonstrated the involvement of AMH in the pathophysiology of PCOS, understanding the molecular interactions of AMH with other proteins in the context of human PCOS remains limited. Therefore, bioinformatics approaches can be used to identify and map the AMH protein interaction network in PCOS and evaluate the involvement of relevant molecular pathways. This study was conducted using a bioinformatics approach to explore protein interactions. The analysis process included collecting datasets of proteins related to AMH and PCOS, modelling protein-protein interaction (PPI) networks, and functional analysis using KEGG pathways and Gene Ontology (GO). The protein interaction shows that AMH plays a central role in PCOS through its influence on follicular development, hormonal regulation, and cellular signalling pathways. The association between AMH in PCOS involves the ovarian steroidogenesis pathway bioinformatically which is targeted in SMAD and TGF B signalling.

 

Biografi Penulis

  • Luluk Hermawati, Departemen Biologi Medis, Program Studi Kedokteran, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Sultan Ageng Tirtayasa, Kota Serang, Indonesia

    Departemen Biologi Medis, Program Studi Kedokteran, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Sultan Ageng Tirtayasa, Kota Serang, Indonesia.

  • Nur Bebi Ulfah Irawati, Departemen Parasitologi , Program Studi Kedokteran, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Sultan Ageng Tirtayasa, , Kota Serang, Indonesia

    Departemen Parasitologi , Program Studi Kedokteran, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Sultan Ageng Tirtayasa, , Kota Serang, Indonesia.

  • Hilizza Awalina Zulfa, Departemen Histologi , Program Studi Kedokteran, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Sultan Ageng Tirtayasa, Kota Serang, Indonesia.

    Departemen Histologi , Program Studi Kedokteran, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Sultan Ageng Tirtayasa, Kota Serang, Indonesia.

Unduhan

Diterbitkan

2025-12-31

Terbitan

Vol 14 No 4 (2025): Jurnal Kedokteran

Bagian

Articles

Lisensi

Hak Cipta (c) 2025 Firda Asma'ul Husna, Luluk Hermawati, Nur Bebi Ulfah Irawati, Hilizza Awalina Zulfa, Ghea Farmaning Thias Putri , Yuda Nabella Prameswari

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