Update on Patophysiology and Management of Complication in Children With Haemophilia: A Literature Review from 2020-2025
DOI:
https://doi.org/10.29303/jk.v14i4.7609Kata Kunci:
arthropathy, children, complication, haemophilia, managementAbstrak
Background: The high prevalence of death in children with haemophilia is often associated with its complications. The complications can worsen the quality of life of children and pose a high economic threat. This emphasizes the need for earlier detection and good management of complications.
Aim: This literature review aims to discuss the pathophysiology and management of complications that can present in paediatric patients with haemophilia.
Method: A literature search of original research, case reports, systematic reviews, and meta-analyses was conducted through Google Scholar, ProQuest, and Wiley. The included articles met the following criteria: year of publication 2020-2025, in English or Indonesian, and at least accompanied by a complete abstract.
Results & Discussion: The total number of articles reviewed was 20 articles. The types of complications that often occur in paediatric patients with haemophilia are haemophilic arthropathy, inhibitor, bleeding, and psychosocial disorders. Management options given for each complication vary, but in general consist of prophylactic transfusion of coagulation factor replacement, physical rehabilitation therapy, pain management, surgery, bypassing agents, gene therapy, and monoclonal antibodies. Each type of management has its own goals and procedures, and modifications to the mode of therapy administration have the potential to provide better outcomes for the severity and disability of the patient.
Summary: Complications of haemophilia in children require more attention from health workers. Acute therapy and prophylaxis remain the main options, with a number of new regimens being developed that are expected to be more widely used and available for people from various social strata.
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Hak Cipta (c) 2025 Ni Wayan Puspa Wijaya Suryantarini
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