Antihypertensive Activity of Aqueous Celery (Apium graveolens) Leaf Extract at Different Dose Levels in a NaCl-Induced Hypertensive Murine Model
DOI:
https://doi.org/10.29303/jk.v15i3.10027Kata Kunci:
Apium graveolens, celery leaf extract, hypertension, antihypertensive activity, herbal medicineAbstrak
Background: Hypertension is a major risk factor for cardiovascular disease, and there is increasing interest in herbal medicines as complementary antihypertensive therapies. Celery (Apium graveolens) has been reported to possess antihypertensive properties; however, evidence comparing the effects of different doses of celery leaf extract remains limited.
Objective: To evaluate the antihypertensive activity of aqueous celery (Apium graveolens) leaf extract at different dose levels in a NaCl-induced hypertensive murine model.
Methods: Twenty-four male mice were rendered hypertensive by administration of 2% NaCl for seven days and were then randomly assigned to four groups (n = 6 per group): a control group and three treatment groups receiving aqueous celery leaf extract at doses of 300, 400, and 500 mg/kg body weight/day for seven consecutive days. Blood pressure was measured at baseline (Day 0), after hypertension induction (Day 7), and after treatment (Day 14). Post-treatment systolic and diastolic blood pressure values were compared among groups using one-way ANOVA followed by Tukey's honestly significant difference (HSD) test.
Results: All treatment groups exhibited lower post-treatment systolic and diastolic blood pressure values than the control group. The 300 mg/kg body weight/day group showed the lowest post-treatment blood pressure values among the tested doses; however, no statistically significant differences were observed among the three treatment groups. Significant differences were identified between each treatment group and the control group (p < 0.05).
Conclusion: Aqueous celery (Apium graveolens) leaf extract demonstrated antihypertensive activity in NaCl-induced hypertensive mice. Within the tested dose range, increasing the dose above 300 mg/kg body weight/day did not provide additional antihypertensive benefit. Further studies evaluating a wider range of doses, longer treatment durations, and maintenance of the hypertensive stimulus are warranted to better characterize the antihypertensive potential of celery leaf extract.
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Hak Cipta (c) 2026 Abraham Ahmad Ali Firdaus, Marselli W. Lestari, Durroh Putri, Ain Darojah Siddiq Ramadhana
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