Tinjauan Pustaka: Peran Vitamin D Terhadap Imunitas

Authors

  • Shafira Dyah Setyawati Program Studi Pendidikan Dokter, Fakultas Kedokteran Universitas Mataram
  • Ima Arum Lestarini Staff Pengajar Bagian Patologi Klinik, Fakultas Kedokteran Universitas Mataram

DOI:

https://doi.org/10.29303/jk.v11i3.4718

Keywords:

Vitamin D, Imunitas Adaptif, Imunitas Bawaan

Abstract

Vitamin D merupakan vitamin larut lemak yang didapatkan dalam jumlah besar
melalui sintesis endogen di kulit dengan bantuan sinar matahari. Vitamin D memiliki
peran klasik yaitu untuk membantu regulasi mineral dan metabolisme tulang. Di sisi
lain, studi baru menunjukkan adanya peran vitamin D terhadap imunitas tubuh
manusia. Peran ini dikarakteristikkan dari adanya presentasi vitamin D receptor
(VDR) serta enzim 1-α-hidroksilase (CYP27B1) pada sel-sel imun. Melalui reseptor
dan enzim tersebut vitamin D dapat memodulasi sistem imun manusia, baik
bawaan maupun adaptif. Peran vitamin D dalam sistem imun bawaan melibatkan
modulasi pada aktivitas monosit atau makrofag dan sel dendritik, sedangkan
peran vitamin D dalam sistem imun adaptif melibatkan modulasi pada aktivitas sel
limfosit B dan sel limfosit T.

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Published

2022-09-30

Issue

Vol. 11 No. 3 (2022): Jurnal Kedokteran

Section

Articles

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