GANGGUAN HEMOSTASIS PADA PENYAKIT GINJAL KRONIK DERAJAT 5

Authors

  • Yusra Pintaningrum Department of Cardiology and Vascular Medicine, West Nusa Tenggara General Hospital, Mataram, Indonesia
  • Djoko Santoso Department of Internal Medicine, Faculty of Medicine-Dr.Soetomo Teaching Hospital, Surabaya, Indonesia
  • Ketut Angga Aditya Putra Pramana Bhayangkara Mataram Hospital, Mataram, Indonesia

DOI:

https://doi.org/10.29303/jk.v11i3.4723

Keywords:

Chronic kidney disease, dialysis, platelet dysfunction, hemostatis

Abstract

Patients with chronic kidney disease (CKD) develop hemostatic disorders mainly in the form of bleeding diatheses. Platelet dysfunction is the main factor responsible for hemorrhagic tendencies in advanced kidney disease. Anemia, dialysis, the accumulation of medications due to poor clearance, and anticoagulation used during dialysis have some role in causing impaired hemostasis in CKD patients. Platelet dysfunction occurs both as a result of intrinsic platelet abnormalities and impaired platelet-vessel wall interaction. The normal platelet response to vessel wall injury with platelet activation, recruitment, adhesion, and aggregation is defective in advanced renal failure. Dialysis may partially correct these defects, but cannot totally eliminate them. The hemodialysis process itself may in fact contribute to bleeding. Hemodialysis is also associated with thrombosis as a result of chronic platelet activation due to contact with artificial surfaces during dialysis.

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Published

2022-09-30

Issue

Vol. 11 No. 3 (2022): Jurnal Kedokteran

Section

Articles

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