Brain Injury and Neurocognitive Problem in Cerebral Malaria

Authors

  • Eriska Hidayati Fakultas Kedokteran Universitas Mataram
  • Ilsa Hunaifi Fakultas Kedokteran Universitas Mataram

DOI:

https://doi.org/10.29303/jk.v12i1.4351

Keywords:

Malaria cerebral, brain injury, plasmodium falcifarum

Abstract

Malaria serebral (CM), hasil dari infeksi Plasmodium falciparum , dan memiliki angka kematian yang tinggi. Penyintas CM dapat mempertahankan gejala sisa pasca CM seumur hidup, termasuk kejang dan defisit neurokognitif yang sangat mempengaruhi kualitas hidup mereka. Karena parasit Plasmodium tidak masuk ke otak, tetapi berada di dalam eritrosit dan terbatas pada lumen pembuluh darah otak, neuropatogenesis yang menyebabkan gejala sisa neurologis ini tidak jelas dan kurang diteliti lebih lanjut. Menariknya, patologi CM postmortem berbeda di daerah otak, seperti munculnya punctae hemoragik dalam warna putih versusmateri abu-abu. Berbagai faktor inang dan parasit berkontribusi pada risiko CM, termasuk paparan pada usia muda, genetika terkait parasit dan inang, penyerapan parasit dan tingkat respons inflamasi inang.Sejauh ini, beberapa perawatan tambahan yang diusulkan belum berhasil dalam pengobatan CM.  Perhatian lebih pada hal ini dapat mengarah pada pengembangan pengobatan tambahan yang efektif untuk mengatasi gejala sisa neurologis CM.

Downloads

Published

2023-03-31

Issue

Vol. 12 No. 1 (2023): Jurnal Kedokteran

Section

Articles

License

Authors who publish with Unram Medical Journal, agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License (CC-BY License). This license allows authors to use all articles, data sets, graphics, and appendices in data mining applications, search engines, websites, blogs, and other platforms by providing an appropriate reference. The journal allows the author(s) to hold the copyright without restrictions and will retain publishing rights without restrictions.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in University of Mataram's Journal of Medicine. 
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
  4. This journal is open access journal which means that all content is freely available without charge to users or / institution. Users are allowed to read, download, copy, distribute, print, search, or link to full text articles in this journal without asking prior permission from the publisher or author.