Autoimmune Hemolytic Anemia (AIHA)

Authors

  • Hifzani Nurmuliani Program Studi Pendidikan Dokter, Fakultas Kedokteran Universitas Mataram
  • Ayu Santia Dewi Program Studi Pendidikan Dokter, Fakultas Kedokteran Universitas Mataram
  • Mohammad Rizki Fakultas Kedokteran Universitas Mataram/Rumah Sakit Universitas Mataram

DOI:

https://doi.org/10.29303/jk.v12i1.4349

Keywords:

AIHA, Anemia Hemolitik Autoimun, Coombs test, CAD

Abstract

Anemia hemolitik autoimun (Autoimmune Hemolytic Anemia = AIHA / AHA) adalah sebuah kelainan pada eritrosit yang ditandai dengan kerusakan eritrosit oleh autoantibodi dalam tubuh seseorang. AIHA dapat terjadi pada semua kalangan usia, namun paling sering menyerang usia di atas 40 tahun. Angka kejadiannya sebesar 17:100.000 orang per tahun dengan angka kematian hingga 11%. Secara umum AIHA terjadi secara intravaskuler dan ekstravaskuler dengan aktivasi komplemen atau tanpa aktivasi komplemen. Pada pasien AIHA biasanya mengalami pucat, lemas, dispnea, hipotensi, takikardi, ikterus pada mukosa kulit, splenomegali, dan hepatomegali. Untuk menegakkan diagnosis AIHA selain dari anamnesis dan pemeriksaan fisik, juga didapatkan dari pemeriksaan laboratorium yaitu berupa pemeriksaan darah lengkap, indeks eritrosit, LDH, bilirubin indirek, retikulosis, serta morfologi darah tepi. Selain itu perlu dilakukan juga pemeriksaan untuk mendeteksi autoantibodi pada eritrosit. Pemeriksaan ini biasa dikenal sebagai Coombs test yaitu berupa direct Coombs test (Direct Antiglobulin Test/DAT) dan indirect Coombs test (Indirect Antiglobulin Test/IAT).

Downloads

Published

2023-03-31

Issue

Vol. 12 No. 1 (2023): Jurnal Kedokteran

Section

Articles

License

Authors who publish with Unram Medical Journal, agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License (CC-BY License). This license allows authors to use all articles, data sets, graphics, and appendices in data mining applications, search engines, websites, blogs, and other platforms by providing an appropriate reference. The journal allows the author(s) to hold the copyright without restrictions and will retain publishing rights without restrictions.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in University of Mataram's Journal of Medicine. 
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
  4. This journal is open access journal which means that all content is freely available without charge to users or / institution. Users are allowed to read, download, copy, distribute, print, search, or link to full text articles in this journal without asking prior permission from the publisher or author.