Lombok Medical Journal
type: channel
description: Lombok Medical Journal (LMJ) is scientific, peer-reviewed, and open access journal published by Faculty of Medicine, Universitas Mataram, West Nusa Tenggara, Indonesia.
publisher: Faculty of Medicine, Universitas Mataram
language: en
publication name: Lombok Medical Journal
issn: 2827-7686
items: Insulin Enhances the Viability of Doxorubicin-Exposed Luminal A Breast Cancer T-47D Cells
items: Insulin-Induced NF-κB Activation May Contribute to Doxorubicin Resistance in Luminal A T-47D Breast Cancer Cells
items: Review Article: The Potential of Terpenoids from Marine Organisms as Neuroprotective Agents in Peripheral Neuropathy
items: In Vitro Cultivation of 3D Umbilical Cord MSC Spheroid Model for Chondrogenic Differentiation
items: The Effects of Turmeric, Aloe Vera, and Honey as Natural Remedies for Reducing Scar Visibility_ A Pilot Clinical Trial
items: The Potency of Atorvastatin Nanoparticles Implementation in Human: A Pharmacokinetic Perspective from Basic to Clinical Literature Review
items: Evaluation of Solanum lasiocarpum Fruit Extract on Blood Glucose, Hematological Parameters, and Liver and Kidney Function in Alloxan-induced Diabetic Rats
items: Bilateral Pleural Effusion as a Rare Manifestation of Snakebite Envenomation: A Case Report
items: Insiden Pneumotoraks setelah Prosedur Intervensi Paru: Systematic Review
items: Perjalanan Udara dengan Penyakit Paru
items: Multiple Cranial Nerve Palsy (MCNP) in Cerebral Sinus Vein Thrombosis (CSVT) due to Bilateral Septic Cavernous Sinus Granulomatous Abscess and Multiple Sinusitis: A Case Report
items: Peran Tim Multidisiplin dalam Penatalaksanaan Limfoma Non-Hodkin Stadium IV yang Kompleks: Laporan Kasus
items: Krisis Penyakit Tidak Menular pada Usia Muda: Dari Faktor Risiko ke Strategi Pencegahan
items: Faktor-faktor yang Berhubungan dengan Kelengkapan Imunisasi Dasar Pada Anak Usia 9-24 Bulan di Wilayah Kerja Puskesmas Jatibaru Kota Bima
items: Diagnosis dan Tatalaksana Prostatitis
items: Cedera Paru pada Near Drowning : Patofisiologi dan Penatalaksanaan
items: Acute Kidney Injury in 43 Years Old Male Patient Caused by Severe Leptospirosis
items: Rasio Neutrofil - Limfosit sebagai Prediktor Hasil Klinis pada Pasien dengan PPOK Eksaserbasi Akut: Tinjauan Literatur
items: Paparan Timbal dan Stres Oksidatif: Dampak Klinis dan Mekanismenya
items: Optimalisasi Nanopartikel Lipid Eksopolisakarida Termodifikasi Asam Folat untuk Penghantaran Trastuzumab Biosimilar Target HER2 pada Kanker Payudara
items: The Role of Galactose-induced Oxidative Stress on Cellular Aging: A Literature Review
items: Paradoxical Reactions in Tuberculous Meningitis : Clinical Insight and Management, a Literature Review
items: Analisis Faktor yang Berhubungan dengan Kejadian Seksio Sesarea Berulang di Rumah Sakit Umum Daerah Kota Kendari Periode 2023-2024
items: Oral Cancer and Reconstruction: A Serial Case Report
items: Diagnosis dan Tatalaksana Postherpetic Neuralgia
items: Mengenal Human Metha Pneumo Virus (HMPV) yang merebak di beberapa Negara
items: Klasifikasi dan Faktor Risiko Ruptur Aneurisma Intrakranial; Sebuah Tinjauan Pustaka
items: Analisis Kelayakan Integrasi Otopsi Virtual dalam Sistem Visum et Repertum di Indonesia: Perspektif Medis, Yuridis, dan Teknologis
items: Additionally, the Author Examines the Management, Prognosis, and Complications Associated with RBBB.
items: A Case Report Disfonia et causa Nodul Vocal Cords Bilateral

Insulin Enhances the Viability of Doxorubicin-Exposed Luminal A Breast Cancer T-47D Cells
type: item
description: Breast cancer is one of the most common cancers worldwide, with a high incidence rate. Doxorubicin is a chemotherapeutic agent used in breast cancer management. Nevertheless, chemoresistance remains a major challenge in breast cancer chemotherapy. Insulin contributes to chemoresistance through its mitogenic and prosurvival activities. To date, studies evaluating the effect of insulin on the viability of Luminal A breast cancer cells (T-47D) under doxorubicin exposure remain limited. This study aimed to analyse the effect of insulin supplementation on the viability of Luminal A breast cancer cells (T-47D) exposed to doxorubicin. An in vitro experimental study was conducted using T-47D cells treated with doxorubicin at various concentrations (3.13, 6.25, 12.5, 25, 50, and 100 μg/mL), with and without insulin supplementation. Cell viability was assessed using the 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and analysed using a paired-samples t-test. T-47D cells receiving insulin supplementation showed higher viability than those without insulin across all tested doxorubicin concentrations, with statistically significant differences (p < 0.05). The fold change in viability between the insulin and non-insulin groups increased with rising doxorubicin concentrations. In conclusion, insulin affects the viability of Luminal A breast cancer T-47D cells exposed to doxorubicin, indicating reduced cellular sensitivity to the cytotoxic effects of doxorubicin.
subject: Articles
  topic: section
subject: doxorubicin
  topic: keywords
subject: insulin
  topic: keywords
subject: breast cancer
  topic: keywords
subject: T-47D cell
  topic: keywords
creator: Fadhilla Resendryana Esthya
creator: Novrita Padauleng
creator: Lale Maulin Prihatina
rights: Copyright (c) 2026 Lombok Medical Journal
date: 2026-08-20
publication date: 2026-08-20
starting page: 149
ending page: 157
doi: 10.29303/tv98zw69

Insulin-Induced NF-κB Activation May Contribute to Doxorubicin Resistance in Luminal A T-47D Breast Cancer Cells
type: item
description: Doxorubicin is an effective chemotherapy agent for breast cancer; however, its efficacy is often limited by cellular resistance. Insulin is hypothesized to enhance anti-apoptotic activity through activation of Nuclear Factor Kappa-Beta (NF-κB), although its mechanism in the Luminal A subtype T-47D cell line has not been extensively studied. This analytical experimental study with a post-test only paired design used T-47D cells divided into insulin-treated and non-insulin groups. Both groups were exposed to various concentrations of doxorubicin, namely 0 (control), 3.125, 6.25, 12.5, 25, 50, and 100 µg/mL. NF-κB activation was measured as pNF-κB concentration using the ELISA method. Data were analyzed using the Shapiro–Wilk test for normality followed by a paired t-test. The insulin-treated group showed higher mean pNF-κB concentrations compared to the non-insulin group across all doxorubicin doses. Significant differences were observed at 0 µg/mL (p = 0.008), 3.125 µg/mL (p = 0.009), and 100 µg/mL (p = 0.045), whereas no significant differences were found at concentrations between 6.25 and 50 µg/mL (p > 0.05). Overall, increasing doxorubicin concentrations reduced pNF-κB levels; however, insulin treatment maintained higher pNF-κB levels compared to the non-insulin group. These findings indicate that insulin increases NF-κB activation in doxorubicin-treated T-47D breast cancer cells and may sustain NF-κB activity against the cytotoxic effects of doxorubicin.
subject: Articles
  topic: section
subject: breast cancer
  topic: keywords
subject: doxorubicin
  topic: keywords
subject: insulin
  topic: keywords
subject: NF-κB
  topic: keywords
subject: T-47D
  topic: keywords
subject: chemoresistance
  topic: keywords
creator: Wibisono Hasanul Muhtaram
creator: Novrita Padauleng
creator: Rizka Vidya Lestari
rights: Copyright (c) 2026 Lombok Medical Journal
date: 2026-07-31
publication date: 2026-07-31
starting page: 114
ending page: 121
doi: 10.29303/jzdrrk18

Review Article: The Potential of Terpenoids from Marine Organisms as Neuroprotective Agents in Peripheral Neuropathy
type: item
description: Peripheral neuropathy is a common neurological disorder, particularly in patients with diabetes mellitus and older adults, with limitations of current therapies prompting the search for alternative treatments. This narrative review aims to evaluate the potential of marine-derived terpenoids as neuroprotective agents in peripheral neuropathy. Terpenoids demonstrate multi-target mechanisms, including antioxidant and anti-inflammatory effects, ion channel modulation, and regulation of signaling pathways such as phosphoinositide 3-kinase/protein kinase B (PI3K/Akt), Mitogen Activated Protein Kinase (MAPK), and nuclear factor erythroid 2 related factor 2 (Nrf2). These actions contribute to reduced oxidative stress, suppression of neuroinflammation, and improved neuronal survival. Compounds such as astaxanthin show promising effects in reducing neuropathic pain, although evidence remains largely preclinical. Clinical translation is limited by low bioavailability and insufficient long term safety data. Further studies are required to confirm their therapeutic potential.
subject: Articles
  topic: section
creator: Shafira Adinda Putri
creator: Baiq Rizqika Catur Putri
creator: Mulayanatul Aliyyah
creator: Fito Danang Sofiandi
creator: Ilsa Hunaifi
rights: Copyright (c) 2026 Lombok Medical Journal
date: 2026-08-05
publication date: 2026-08-05
starting page: 136
ending page: 148
doi: 10.29303/t0mcbk23

In Vitro Cultivation of 3D Umbilical Cord MSC Spheroid Model for Chondrogenic Differentiation
type: item
description: Cartilage is a tissue that specifically difficult to heal when injured due to its avascular, aneural, and alymphatic nature, in addition to the limited ability of cells to migrate in the tissue for repair. Human umbilical cord–derived mesenchymal stem cells (hUC-MSCs) possess promising chondrogenic potential, particularly when cultured in three-dimensional (3D) systems that better mimic the native tissue environment. It is important to note that the current study is limited to an in vitro setting, and no in vivo experiments were conducted. This work aimed to evaluate the ability of hUC-MSCs to undergo chondrogenic differentiation over time using a 3D spheroid culture system. hUC-MSCs were isolated from umbilical cords of two donors, expanded to passage 5, and seeded into ultra-low attachment well plates with chondrogenic differentiation medium. Spheroids were incubated for 14 and 21 days. Chondrogenesis was assessed by crystal violet staining, and collagen deposition was analyzed microscopically and quantified using ImageJ software. Statistical analysis was performed using one-way ANOVA with Tukey’s post-hoc test. hUC-MSCs successfully formed spheroids and demonstrated progressive chondrogenic differentiation over time, marked by increasing collagen deposition. Significant increases in cartilage-positive areas were observed on day 14 (p<0.01) and further on day 21 (p<0.05), indicating enhanced cartilage matrix formation in vitro. Three-dimensional spheroid culture of hUC-MSCs effectively promotes chondrogenic differentiation, with substantial collagen accumulation observed after 21 days. This in vitro model provides a valuable platform for studying the sequential mechanisms of cartilage formation and holds potential for future applications in cartilage tissue engineering.
subject: Articles
  topic: section
subject: 3D spheroid culture
  topic: keywords
subject: chondrogenic differentiation
  topic: keywords
subject: MSCs
  topic: keywords
subject: umbilical cord
  topic: keywords
creator: Bayu Tirta Dirja
creator: I Gusti Ayu Sri Andayani
creator: Yulfa Rizky Amita
creator: Ahmad Taufik S
creator: Dewi Suryani
creator: Mohammad Rizki
rights: Copyright (c) 2026 Lombok Medical Journal
date: 2026-07-31
publication date: 2026-07-31
starting page: 122
ending page: 129
doi: 10.29303/feh9kq25

The Effects of Turmeric, Aloe Vera, and Honey as Natural Remedies for Reducing Scar Visibility_ A Pilot Clinical Trial
type: item
description: Background: Managing scars effectively is often difficult because most clinical treatments are either too expensive or too invasive for many patients. While ingredients like turmeric, honey, and aloe vera have been used in traditional healing for centuries, we still lack enough clinical evidence on how they perform when combined into a single topical remedy. Purpose: This pilot trial was designed to test the safety and effectiveness of a simple, low-cost natural formulation in improving the appearance of both discolored (dyschromic) and raised (hypertrophic) scars. Methods: We followed ten participants with scars aged between 1 and 12 months. For four weeks, they applied a homemade blend of fresh aloe vera, honey, turmeric, lemon juice, and niacinamide twice daily. To ensure our results were objective, we used 3D imaging to measure scar height and tracked changes in pigmentation. We also gathered direct feedback from the participants regarding scar softness and redness. Results: The outcomes were notably positive. After the month-long treatment, 64% of the volunteers saw their scars flatten by at least 20%, with the most significant changes occurring in hypertrophic cases. Furthermore, 72% of the group showed visible lightening of their skin pigment. The formula worked best on acute scars (under six months old). Participants found the mixture easy to use and reported no side effects, other than a temporary yellow stain from the turmeric that faded quickly. Conclusion: Our findings suggest that this natural blend is a practical and affordable way to improve the texture and color of developing scars. While these initial results are promising, we believe larger, randomized trials are needed to standardize the recipe and confirm its long-term benefits.
subject: Articles
  topic: section
subject: Turmeric
  topic: keywords
subject: Aloe vera
  topic: keywords
subject: Honey
  topic: keywords
subject: Dyschromic scars
  topic: keywords
creator: Nour Hatem
creator: Wiriatul hasanah
creator: Shahd Rashad
creator: Abdelaziz gomaa
creator: Muji iswanty
rights: Copyright (c) 2026 Lombok Medical Journal
date: 2026-08-05
publication date: 2026-08-05
starting page: 130
ending page: 135
doi: 10.29303/ce2ryc12

The Potency of Atorvastatin Nanoparticles Implementation in Human: A Pharmacokinetic Perspective from Basic to Clinical Literature Review
type: item
description: Atorvastatin is a biopharmaceutics classification system class II drug with good permeability but low solubility, thereby limiting its bioavailability and therapeutic efficacy. This study aims to analyze the effect of particle size reduction on the pharmacokinetic parameters (Cmax, Tmax, AUC, t½) of atorvastatin in various drug delivery systems and the potency of its implementation in human through a literature review approach. Literature screening was conducted using online databases including Google Scholar, PubMed, ScienceDirect, and Springer Open, with inclusion criteria of national and international articles published in the last 10 years discussing atorvastatin formulations with various particle sizes and their pharmacokinetic parameters. Analysis of the 11 selected articles showed that nano-based delivery systems can increase the bioavailability of atorvastatin compared to conventional formulations. The results confirmed that particle size reduction through nanotechnology approaches increased the dissolution rate, membrane permeability, and absorption efficiency, thereby optimizing the pharmacokinetic profile of atorvastatin. This review provides evidence that nano-scale formulation strategies have a consistent positive impact on the bioavailability of atorvastatin. Despite these promising preclinical findings, the implementation of atorvastatin nanoparticles in humans remains limited due to the absence of clinical trials, although their potency to improve bioavailability and reduce dose-dependent toxicity at lower doses offers a strong rationale for future translational research.
subject: Articles
  topic: section
subject: Atorvastatin
  topic: keywords
subject: Drug delivery system
  topic: keywords
subject: Nanoparticles
  topic: keywords
subject: Particle size
  topic: keywords
creator: Candra Dwipayana Hamdin
creator: Vania Aisyah Aulia Syahda Haris
creator: Steve Pratama Tanjaya
creator: Shafira Khansa Haiba
creator: Faolananda Qurrota A'yun
rights: Copyright (c) 2026 Lombok Medical Journal
date: 2026-05-31
publication date: 2026-05-31
starting page: 105
ending page: 113
doi: 10.29303/e9cn9w04

Evaluation of Solanum lasiocarpum Fruit Extract on Blood Glucose, Hematological Parameters, and Liver and Kidney Function in Alloxan-induced Diabetic Rats
type: item
description: Hyperglycemia is an increase in blood glucose levels that leads to diabetes mellitus. Diabetes mellitus caused by insulin resistance and impaired insulin secretion. Eggplant (Solanum lasiocarpum) is an herbal plant used as a traditional remedy for diabetes mellitus. This study aims to determine the effect of Eggplant fruit extract (S. lasiocarpum) on blood glucose, blood profile, SGPT, SGOT, creatinine, and ureum levels in diabetic rats. This study used a completely randomized design with six groups (G1: normal control, G2: diabetes control, G3: metformin control, G4: extract dose 200 mg/kg BW; G5: extract dose 300 mg/kg BW; and G6: extract dose 400 mg/kg BW. Measurement of SGPT, SGOT, Urea, and Creatinine levels using a spectrophotometer. Data analysis uses one-way ANOVA and Duncan at a significance level of 0.05. Statistical analysis revealed a significant difference (p<0.05) between the control group and extract therapy in blood glucose, blood profile tests, SGPT, SGOT, creatinine, and urem. The optimal dose of S. lasiocarpum fruit extract to reduce the effects caused by diabetes was 400 mg/kg BW.
subject: Articles
  topic: section
subject: diabetes mellitus
  topic: keywords
subject: Solanum lasiocarpus
  topic: keywords
subject: SGPT; SGOT
  topic: keywords
subject: ureum
  topic: keywords
subject: creatinine
  topic: keywords
creator: Syukriah
creator: Nurlian Augustin Ningrum
creator: Siti Amira
rights: Copyright (c) 2026 Lombok Medical Journal
date: 2026-05-16
publication date: 2026-05-16
starting page: 83
ending page: 94
doi: 10.29303/gq0svd83

Bilateral Pleural Effusion as a Rare Manifestation of Snakebite Envenomation: A Case Report
type: item
description: Background: Snakebite envenomation remains a significant global health problem, particularly in tropical regions, with a wide spectrum of clinical manifestations ranging from local tissue injury to life-threatening systemic complications. While coagulopathy, neurotoxicity, and acute kidney injury are commonly reported, pleural effusion is an uncommon manifestation and may indicate severe systemic involvement. Case Presentation : We report a 38-year-old male with grade III snakebite in the right cervical region who developed progressive local swelling, hematoma, and systemic symptoms including dyspnea. The patient experienced radiating pain from the neck to the right upper limb and chest, followed by decreased consciousness and worsening respiratory distress. Physical examination revealed extensive edema involving the neck, chest, and right upper extremity. Dyspnea worsened in the supine position and improved in a semi-upright position, suggesting pleural involvement. Laboratory findings showed leukocytosis and thrombocytopenia, while chest radiography confirmed right-sided pleural effusion with pulmonary infiltrates. Discussion : Pleural effusion in snakebite is rare and is likely caused by increased vascular permeability, systemic inflammatory response, and coagulopathy induced by venom components such as metalloproteinases and phospholipase A2. These mechanisms contribute to capillary leak syndrome and fluid accumulation in the pleural space. Conclusion : Pleural effusion should be considered in patients with severe snakebite presenting with respiratory symptoms. Early recognition and prompt management, including antivenom therapy and supportive care, are essential to prevent clinical deterioration.
subject: Articles
  topic: section
subject: Snakebite
  topic: keywords
subject: Envenomation
  topic: keywords
subject: Hemorrhagic Pleural Effusion
  topic: keywords
subject: Coagulopathy
  topic: keywords
subject: Respiratory Complications
  topic: keywords
creator: Faria Yunita Utami
creator: Gemilang Khusnurrokhman
rights: Copyright (c) 2026 Lombok Medical Journal
date: 2026-05-16
publication date: 2026-05-16
starting page: 76
ending page: 82
doi: 10.29303/vh0yh252

Insiden Pneumotoraks setelah Prosedur Intervensi Paru: Systematic Review
type: item
description: Diagnostic management of peripheral lung lesions and diffuse lung parenchymal disease faces major challenges in balancing diagnostic accuracy with the risk of complications. Pneumothorax is the most frequently reported iatrogenic complication and can increase morbidity, the need for emergency intervention, and patient length of hospital stay. This study aims to systematically evaluate the incidence of pneumothorax and the requirement for thoracic drainage in various lung intervention methods to provide safety-focused procedural selection guidance. This systematic review was prepared following PRISMA guidelines with a comprehensive literature search on PubMed, Cochrane Library, and Frontiers databases. Analysis revealed significant risk variation between intervention methods. CT-guided percutaneous transthoracic lung biopsy (CT-PTLB) procedures showed the highest risk, with pneumothorax rates reaching 25.9% and chest tube requirements at 6.9%. Conversely, transbronchial techniques offer a better safety profile, where conventional transbronchial lung biopsy has a pneumothorax incidence of 1-6%, r-EBUS approximately 1.4-5.0%, and transbronchial cryobiopsy between 6-10%. Risk factors such as emphysema, lesion depth >2 cm, and the use of larger needle sizes (18G) were identified as strong predictors of pneumothorax. Selection of the appropriate technique and patient positioning (biopsy-side down) are highly recommended to minimize complications while maintaining patient safety.
subject: Articles
  topic: section
subject: pneumothorax
  topic: keywords
subject: lung biopsy
  topic: keywords
subject: CT-PTLB
  topic: keywords
subject: transbronchial cryobiopsy
  topic: keywords
subject: procedural safety
  topic: keywords
creator: Syabila Andini
creator: Gemilang Khusnurrokhman
rights: Copyright (c) 2026 Lombok Medical Journal
date: 2026-04-17
publication date: 2026-04-17
starting page: 54
ending page: 59
doi: 10.29303/dd3y8n39

Perjalanan Udara dengan Penyakit Paru
type: item
description: Perjalanan udara pada umumnya aman bagi individu sehat, namun pada pasien dengan penyakit pernapasan diperlukan pertimbangan medis yang cermat karena paparan hipoksia hipobarik setara ketinggian kabin hingga 2438 m dapat memicu hipoksemia bermakna. Gangguan pernapasan menyumbang sekitar 12% dari seluruh keadaan darurat medis dalam penerbangan dan menjadi salah satu penyebab utama pengalihan penerbangan. Sebagian besar kejadian tersebut berkaitan dengan kondisi medis yang telah ada sebelumnya. Oleh karena itu, skrining dan evaluasi pra-penerbangan yang sistematis menjadi strategi penting untuk mencegah komplikasi selama dan setelah perjalanan udara.
subject: Articles
  topic: section
subject: Perjalanan Udara
  topic: keywords
subject: Hypoxic Challenge Test
  topic: keywords
subject: Oksigen dalam Penerbangan
  topic: keywords
creator: Mc Syaiful Ghazi Yamani
creator: Indana Eva Ajmala
creator: Salim S. Thalib
creator: Gemilang Khusnurrokhman
creator: Prima Belia Fathana
rights: Copyright (c) 2026 Lombok Medical Journal
date: 2026-05-16
publication date: 2026-05-16
starting page: 95
ending page: 104
doi: 10.29303/7tj7c298

Multiple Cranial Nerve Palsy (MCNP) in Cerebral Sinus Vein Thrombosis (CSVT) due to Bilateral Septic Cavernous Sinus Granulomatous Abscess and Multiple Sinusitis: A Case Report
type: item
description: Case reports about cavernous sinus venous thrombosis (CSVT) with ophtalmoplegia are relatively rare caused by a long-standing dental infection complicated by a history of long-term smoking, leading to granulomatous abscesses and multiple sinusitis. A 48-year-old man admitted to the Emergency Department presenting of an inability to lift his left eyelid and to move his eyeball in any direction for the past 3 days, the symptoms were experienced suddenly. Multiple cranial nerves palsy (MCNP) or ophtalmoplegia in CSVT is a neurological disorder involving more than two non-homologous cranial nerves simultaneously. CSVT in this case occurs as a result of inflammation in response to granulomatous abscess of the cavernous sinus and multiple sinusitis due to a longterm untreated history of dental infection with long history of smoking. Clinical accompanying was progressive headache, ophtalgia, ptosis and proptosis. This case report highlights the importance of neuroimaging examinations, particularly CT scans, MRI, and MRA of the head, as the primary standard for establishing a diagnosis of CSVT, thereby enabling appropriate evaluation therapy and substantially determining a favorable prognosis
subject: Articles
  topic: section
subject: cavernous sinus venous thrombosis
  topic: keywords
subject: multiple cranial nerves palsy
  topic: keywords
subject: granulomatous abscess
  topic: keywords
subject: multiple Sinusitis
  topic: keywords
subject: ophtalmoplegia
  topic: keywords
creator: M. Ikhlas Muttaqin Aditiarman
creator: M. Sofyan Faridi
creator: I Wayan Tunjung
creator: Dhesty Fadhilah Faatin
rights: Copyright (c) 2026 Lombok Medical Journal
date: 2026-04-27
publication date: 2026-04-27
starting page: 60
ending page: 68
doi: 10.29303/dbq0zm27

Peran Tim Multidisiplin dalam Penatalaksanaan Limfoma Non-Hodkin Stadium IV yang Kompleks: Laporan Kasus
type: item
description: Abstract : The management of advanced stage non-Hodgkin lymphoma is increasingly complex due to rapid advances in diagnostic and therapeutic modalities and the involvement of multiple medical disciplines. A multidisciplinary team (MDT) approach is widely recognized as the gold standard in cancer care, enabling coordinated, evidence-based, and patient-centered decision-making. This case report describes the role of MDT in the management of a 57-year-old woman with stage IV diffuse large B-cell lymphoma complicated by multisystem involvement. Through structured MDT discussions, optimal multimodal therapy was delivered, clinical complications were effectively managed, and significant clinical improvement was achieved within a relatively short hospitalization period, despite limited healthcare resources. This case highlights that the MDT approach is feasible and beneficial in resource-limited healthcare settings. Abstrak: Penatalaksanaan kanker, khususnya limfoma non-Hodgkin stadium lanjut, semakin kompleks seiring dengan perkembangan pesat modalitas diagnostik dan terapi serta keterlibatan berbagai disiplin medis. Pendekatan tim multidisiplin (multidisciplinary team / MDT) telah diakui sebagai standar emas dalam perawatan kanker karena memungkinkan pengambilan keputusan klinis yang terkoordinasi, berbasis bukti, dan berorientasi pada pasien. Laporan kasus ini menggambarkan peran MDT dalam penatalaksanaan seorang pasien perempuan usia 57 tahun dengan diffuse large B-cell lymphoma stadium IV yang disertai komplikasi multisistem. Melalui diskusi MDT yang terstruktur, pasien mendapatkan terapi multimodal yang optimal, komplikasi klinis dapat ditangani secara efektif, dan perbaikan klinis tercapai dalam waktu rawat inap yang relatif singkat meskipun berada pada fasilitas pelayanan kesehatan dengan keterbatasan sumber daya. Laporan kasus ini menegaskan bahwa pendekatan MDT tetap feasible dan bermanfaat dalam meningkatkan kualitas perawatan kanker di rumah sakit daerah.
subject: Articles
  topic: section
subject: MDT
  topic: keywords
subject: tumor board
  topic: keywords
subject: Limfoma non-Hodkin
  topic: keywords
subject: Cancer care
  topic: keywords
creator: Stevia Ariella
creator: Joko Anggoro
creator: Gemilang Khusnurrokhman
rights: Copyright (c) 2026 Lombok Medical Journal
date: 2026-04-15
publication date: 2026-04-15
starting page: 45
ending page: 49
doi: 10.29303/3rbxe444

Krisis Penyakit Tidak Menular pada Usia Muda: Dari Faktor Risiko ke Strategi Pencegahan
type: item
description: Non-communicable diseases (NCDs) are increasingly burdening the productive-age population, indicating an epidemiological shift toward an earlier onset of chronic diseases. Both global and national levels, hypertension and diabetes show high trends among younger age groups, including at the regional level. This situation is driven by the accumulation of risk factors in adolescence, such as physical inactivity, unhealthy diets, sedentary behavior, smoking, and psychosocial stress, reflecting the multidimensional nature of NCDs. Therefore, prevention must be implemented comprehensively from adolescence through lifestyle interventions, supportive social environments, public policies that promote healthy behaviors, and active youth participation. The integration of mental health into primary care is also essential to strengthen long-term NCD control
subject: Articles
  topic: section
subject: Non communicable disease
  topic: keywords
subject: Productive age
  topic: keywords
subject: Adolescence
  topic: keywords
subject: Risk factor
  topic: keywords
subject: Preventive
  topic: keywords
creator: Marisa Syavitri Dilaga
rights: Copyright (c) 2026 Lombok Medical Journal
date: 2026-01-31
publication date: 2026-01-31
starting page: 37
ending page: 39
doi: 10.29303/yewnak29

Faktor-faktor yang Berhubungan dengan Kelengkapan Imunisasi Dasar Pada Anak Usia 9-24 Bulan di Wilayah Kerja Puskesmas Jatibaru Kota Bima
type: item
description: Latar Belakang: Imunisasi dasar merupakan upaya penting dalam pencegahan penyakit yang dapat dicegah dengan imunisasi (PD3I) pada anak. Meskipun program imunisasi rutin telah dilaksanakan secara nasional, cakupan imunisasi dasar lengkap di Indonesia masih belum mencapai target. Oleh karena itu, diperlukan kajian mengenai faktor-faktor yang memengaruhi kelengkapan imunisasi dasar pada anak. Tujuan: Mengetahui faktor-faktor yang berhubungan dengan kelengkapan imunisasi dasar pada anak usia 9–24 bulan di wilayah kerja Puskesmas Jatibaru, Kota Bima. Metode: Penelitian ini merupakan studi analitik observasional yang dilaksanakan pada September–Oktober 2024. Sebanyak 46 anak usia 9–24 bulan dilibatkan sebagai subjek penelitian. Data dikumpulkan melalui kuesioner kepada ibu serta verifikasi buku KIA dan catatan imunisasi Puskesmas. Variabel yang dianalisis meliputi tingkat pendidikan ibu, tingkat pengetahuan ibu, status pekerjaan ibu, pendapatan keluarga, jumlah anak dalam keluarga, keterjangkauan tempat imunisasi, cara menuju tempat imunisasi, dan dukungan keluarga. Analisis data dilakukan menggunakan SPSS versi 26.0. Hasil: Hasil analisis menunjukkan adanya hubungan yang bermakna antara tingkat pengetahuan ibu (p=0,036), status pekerjaan ibu (p=0,032), dan tingkat pendapatan keluarga (p=0,044) dengan kelengkapan imunisasi dasar pada anak. Variabel lainnya tidak menunjukkan hubungan yang signifikan secara statistik. Kesimpulan: Tingkat pengetahuan ibu, status pekerjaan ibu, dan pendapatan keluarga merupakan faktor yang berhubungan dengan kelengkapan imunisasi dasar pada anak usia 9–24 bulan. Peningkatan edukasi imunisasi secara berkelanjutan diperlukan untuk mendukung pencapaian cakupan imunisasi dasar lengkap
subject: Articles
  topic: section
subject: Imunisasi dasar
  topic: keywords
subject: Kelengkapan imunisasi
  topic: keywords
subject: imunisasi anak
  topic: keywords
creator: Zikriyya Melati Rahmany
rights: Copyright (c) 2026 Lombok Medical Journal
date: 2026-04-15
publication date: 2026-04-15
starting page: 40
ending page: 44
doi: 10.29303/cct1y062

Diagnosis dan Tatalaksana Prostatitis
type: item
description: Prostatitis is a common urological condition in men of all ages, ranging from acute and chronic bacterial prostatitis to chronic pelvic pain syndrome (CP/CPPS) and asymptomatic inflammatory prostatitis. The condition is characterized by pelvic pain, lower urinary tract symptoms, and, in some cases, sexual dysfunction, significantly affecting quality of life. Major risk factors include bacterial infection, chronic inflammation, and functional obstruction. Pathophysiology involves bacterial invasion, immune response, and neuromuscular dysfunction in CP/CPPS. Management depends on the type of prostatitis and includes antibiotics for bacterial prostatitis, alpha-blockers, anti-inflammatory agents, and multimodal approaches such as the UPOINT system for CP/CPPS, while asymptomatic cases require monitoring. Early diagnosis and tailored therapy are essential to reduce complications and improve patient outcomes
subject: Articles
  topic: section
subject: Prostatitis
  topic: keywords
subject: Chronic Pelvic Pain Syndrome
  topic: keywords
subject: Bacterial Infection
  topic: keywords
subject: Diagnosis
  topic: keywords
subject: Treatment
  topic: keywords
creator: Ali Ramzi
creator: Fatimah Firza
creator: Hadijatul Qubro
rights: Copyright (c) 2026 Lombok Medical Journal
date: 2026-04-27
publication date: 2026-04-27
starting page: 69
ending page: 75
doi: 10.29303/jzky2q15

Cedera Paru pada Near Drowning : Patofisiologi dan Penatalaksanaan
type: item
description: Near drowning is a major cause of respiratory emergencies and can lead to significant pulmonary complications. Aspiration of water disrupts normal lung function, resulting in hypoxemia, surfactant washout, alveolar collapse, and in severe cases, acute lung injury or ARDS. The extent of injury is influenced by several factors, including the amount of aspirated water, contamination with pathogens, and the victim’s physiological condition at the time of submersion. Both freshwater and seawater aspiration can produce similar clinical consequences, ultimately impairing gas exchange and triggering an inflammatory response in the lungs. Early assessment and management are crucial to prevent deterioration. Key evaluations include monitoring oxygen saturation, arterial blood gases, chest radiography, and continuous clinical observation to detect early signs of respiratory compromise. Management focuses on maintaining adequate oxygenation, preventing further heat loss, and addressing complications such as pulmonary edema or infection. The use of positive end-expiratory pressure (PEEP) may be required in patients who develop significant hypoxemia. Near drowning victims who remain asymptomatic after four to six hours of observation generally have a good prognosis, while those with aspiration require close monitoring due to the risk of delayed respiratory failure.
subject: Articles
  topic: section
subject: near drowning
  topic: keywords
subject: aspiration
  topic: keywords
subject: lung injury
  topic: keywords
subject: respiratory complications
  topic: keywords
subject: ARDS
  topic: keywords
creator: Muhammad Mirsa Nidzarsyah
creator: Suryani Padua Fatrullah
rights: Copyright (c) 2026 Lombok Medical Journal
date: 2026-01-31
publication date: 2026-01-31
starting page: 8
ending page: 14
doi: 10.29303/p15y6284

Acute Kidney Injury in 43 Years Old Male Patient Caused by Severe Leptospirosis
type: item
description: Leptospirosis is a zoonotic infectious disease commonly found in tropical regions, caused by Leptospira interrogans, a pathogenic spirochete. The main reservoir is rodents, especially rats. Human transmission occurs either directly through inoculation from infected animal tissues, body fluids and urine, or indirectly through contact via mucosal surfaces or abraded skin. The excretion of organisms through the urine of infected animals represents the most common source of Leptospira infection. As of mid-2024, 367 cases of leptospirosis with 42 deaths had been reported in Indonesia. However, the true incidence is likely underreported due to diagnostic challenges. In West Nusa Tenggara (NTB), no formal report exists; however, a data from Mataram City Hospital between 2013-2025 recorded three cases of leptospirosis involving renal impairment requiring hemodialysis (HD). The clinical course of leptospirosis is typically acute, following an incubation period of five to fourteen days. Most patients present with mild, anicteric febrile, but a smaller subset develop severe multiorgan involvement known as Weil’s Disease. The severe form is characterized by acute high-grade fever, acute kidney injury, hepatic failure, pulmonary involvement, cardiovascular instability, neurological deficits, and hemorrhagic diathesis.
subject: Articles
  topic: section
subject: Leptospirosis
  topic: keywords
subject: Weil’s Disease
  topic: keywords
subject: Acute Kidney Injury
  topic: keywords
subject: Hemodialysis
  topic: keywords
creator: Ajeng Sulistianing Utami
creator: Amanukarti Resi Oetomo
rights: Copyright (c) 2026 Lombok Medical Journal
date: 2026-04-17
publication date: 2026-04-17
starting page: 50
ending page: 53
doi: 10.29303/adjgba31

Rasio Neutrofil - Limfosit sebagai Prediktor Hasil Klinis pada Pasien dengan PPOK Eksaserbasi Akut: Tinjauan Literatur
type: item
description: Chronic Obstructive Pulmonary Disease (COPD) is a lung disease characterized by chronic respiratory symptoms that cause progressive and persistent airflow obstruction. Numerous inflammatory markers can be used to assess the inflammatory state in COPD patients. Neutrophil-to-Lymphocyte Ratio (NLR) is an inflammatory marker that is easy and practical to examine, which is included in a complete blood count (CBC). We conducted a narrative literature review using a thematic synthesis approach on 12 articles. Five articles demonstrated that the NLR is a good predictor of mortality or death in hospitalized patients with COPD. Two articles stated that a higher NLR in COPD patients increases the likelihood of requiring intensive care (ICU), while the other five articles explained that the NLR can be a good predictor of exacerbations in COPD patients.
subject: Articles
  topic: section
subject: COPD
  topic: keywords
subject: Inflammatory biomarker
  topic: keywords
subject: outcome copd
  topic: keywords
subject: NLR
  topic: keywords
subject: prognostic in COPD
  topic: keywords
creator: Devi Chandra Juvitha
creator: Ni Komang Ayu Swanitri Wangiyana
creator: I Gusti Agung Ayu Eka Putri Sunari
rights: Copyright (c) 2026 Lombok Medical Journal
date: 2026-01-31
publication date: 2026-01-31
starting page: 1
ending page: 7
doi: 10.29303/kpa54229

Paparan Timbal dan Stres Oksidatif: Dampak Klinis dan Mekanismenya
type: item
description: Lead (Pb) exposure is a significant global environmental health concern, as this heavy metal lacks physiological function in the human body and is toxic, leading to various health disorders. One of the primary mechanisms of lead toxicity is the induction of oxidative stress, defined as an imbalance between the production of reactive oxygen species (ROS) and the capacity of endogenous antioxidant systems to neutralize them. Lead enhances ROS generation through mitochondrial dysfunction and reduces the activity of critical antioxidant enzymes, such as superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT), resulting in oxidative damage to lipids, proteins, and DNA, which subsequently triggers cellular and tissue dysfunction. The clinical consequences of lead-induced oxidative stress are observed across multiple organ systems, including the nervous system (cognitive impairment, memory loss, neuropathy), kidneys (nephropathy, decreased filtration function), liver (hepatotoxicity, metabolic disturbances), and the hematopoietic system (anemia, blood cell dysfunction). This literature review indicates that lead exposure induces cellular and tissue damage through multiple cellular pathways related to oxidative stress, elucidating the fundamental mechanisms by which lead causes clinical disorders in these organs. In conclusion, understanding these cellular mechanisms provides a scientific basis for linking lead exposure to the development of multi-organ diseases.
subject: Articles
  topic: section
subject: lead exposure
  topic: keywords
subject: oxidative stress
  topic: keywords
subject: antioxidant enzymes
  topic: keywords
subject: tissue damage
  topic: keywords
creator: Rahmah Dara Ayunda
creator: Ardiana Ekawanti
creator: Fitriannisa Faradina Zubaidi
creator: Khairil Pahmi
creator: Arsy Muchlisa Putri
creator: I Nyoman Rhino Raditya
rights: Copyright (c) 2026 Lombok Medical Journal
date: 2026-01-31
publication date: 2026-01-31
starting page: 15
ending page: 22
doi: 10.29303/98qdar52

Optimalisasi Nanopartikel Lipid Eksopolisakarida Termodifikasi Asam Folat untuk Penghantaran Trastuzumab Biosimilar Target HER2 pada Kanker Payudara
type: item
description: Breast cancer remains a leading cause of cancer-related mortality, with HER2-positive subtypes accounting for 20-30% of cases. While trastuzumab has revolutionized treatment, its efficacy is limited by poor tumor penetration, systemic toxicity, and high costs. This literature review explores folic acid-modified exopolysaccharide lipid nanoparticles (FA-EPS-LNPs) as a novel delivery system for trastuzumab biosimilar. Exopolysaccharides offer biocompatibility and biodegradability, while lipid nanoparticles protect therapeutic proteins and enhance cellular uptake. Folic acid conjugation enables dual targeting through folate receptors overexpressed in cancer cells and HER2-specific activity. The review examines physicochemical properties, optimization parameters including particle size, surface charge, encapsulation efficiency, and folic acid conjugation methods. Evidence demonstrates enhanced cellular uptake, improved cytotoxicity, reduced off-target effects, and superior pharmacokinetics compared to conventional formulations. Challenges include scale-up manufacturing, stability, immunogenicity, and regulatory considerations. This review identifies knowledge gaps and highlights FA-EPS-LNPs' potential to improve treatment outcomes, reduce costs, and enhance patient quality of life in HER2-positive breast cancer therapy.
subject: Articles
  topic: section
subject: HER2+ breast cancer
  topic: keywords
subject: Targeted nanodelivery
  topic: keywords
subject: Folate-modified nanoparticles
  topic: keywords
subject: Trastuzumab biosimilar
  topic: keywords
creator: I Kadek Ari Sanjaya
creator: Baiq Bunga Citra Pratiwi
rights: Copyright (c) 2026 Lombok Medical Journal
date: 2026-01-31
publication date: 2026-01-31
starting page: 23
ending page: 29
doi: 10.29303/7qkkvg78

The Role of Galactose-induced Oxidative Stress on Cellular Aging: A Literature Review
type: item
description: Aging is a complex process impacted by both internal and external causes. Nutrition is a crucial extrinsic factor in the development of aging and degenerative disorders. D-galactose is involved in many aging mechanisms in the brain, heart, liver, kidney, and skin. Galactose-induced cellular aging is primarily caused by oxidative stress and a reduced antioxidant system. Overproduction of ROS can damage proteins, lipids, and DNA. The recommended daily dietary limit for D-galactose is 50 grams for healthy people who can completely remove it within 8 hours. An in vivo study revealed that consuming 150 mg/kg/day of galactose led to metabolic issues, heightened blood pressure, and disrupted cardiac sympathovagal balance. These outcomes resulted from compromised cardiac mitochondrial activity, elevated oxidative stress, inflammation, and mitochondrial dysfunction, which caused cell death and eventually cardiac failure. A diet high in carbohydrates, particularly those derived from dairy products and their derivatives, can lead to the accumulation of galactose and its metabolites within cells. This buildup subsequently increases reactive oxygen species and reduces antioxidant capacity, resulting in mitochondrial dysfunction and heightened oxidative and osmotic stress. The culmination of these processes is a decline in cellular function, senescence, and accelerated organ aging.
subject: Articles
  topic: section
subject: Cellular Aging
  topic: keywords
subject: Galactose
  topic: keywords
subject: Molecular
  topic: keywords
subject: Nutrition
  topic: keywords
subject: Oxidative Stress
  topic: keywords
creator: Putri Krishna Kumara Dewi
creator: Ni Made Dwi Rosmiati
creator: Citra Ariani
rights: Copyright (c) 2026 Lombok Medical Journal
date: 2026-01-31
publication date: 2026-01-31
starting page: 30
ending page: 36
doi: 10.29303/72mdav74

Paradoxical Reactions in Tuberculous Meningitis : Clinical Insight and Management, a Literature Review
type: item
description: Tuberculous meningitis (TBM) is a type of TB with the most severe clinical symptoms of extrapulmonary tuberculosis, with high mortality and neurological morbidity rates. Paradoxical reactions are clinical symptoms characterized by the worsening of existing tuberculosis lesions or the emergence of new lesions despite receiving appropriate antituberculosis therapy (ATT), often leading to diagnostic confusion and management challenges for patients. This study aims to explain the definition, epidemiology, mechanism, clinical manifestations, diagnosis, and management of PR in TBM, based on various literature reviews. The main findings show that PR is triggered by complex immune mechanisms, often involving an excessive inflammatory response to mycobacterial antigens and known as Immune Reconstitution Inflammatory Syndrome (IRIS) in HIV patients. PR presents with varying clinical symptoms, including fever, headache, impaired consciousness, as well as hydrocephalus and tuberculoma on radiological examination. Therefore, clear clinical guidelines are needed to optimize the diagnosis and management of PR in TBM. Keywords: Tuberculous meningitis, paradoxical reaction, IRIS
subject: Articles
  topic: section
subject: Tuberculous meningitis
  topic: keywords
subject: paradoxical reaction
  topic: keywords
subject: IRIS
  topic: keywords
creator: Heni Haryani Heni
creator: Andriyani Andriyani
rights: Copyright (c) 2025 Lombok Medical Journal
date: 2025-10-02
publication date: 2025-10-02
starting page: 122
ending page: 128
doi: 10.29303/lmj.v4i3.591

Analisis Faktor yang Berhubungan dengan Kejadian Seksio Sesarea Berulang di Rumah Sakit Umum Daerah Kota Kendari Periode 2023-2024
type: item
description: Cesarean section (CS) deliveries have increased globally to 30% and reached 25.9% in Indonesia. Kendari City Regional Hospital shows a higher rate of 37.5%, exceeding the WHO recommendation of 30%. This increase is associated with rising risks of morbidity and mortality in both mothers and babies. One of the main contributors is repeat cesarean sections, which account for more than one-third of all cesarean deliveries globally. Repeat cesarean sections carry higher risks of intraoperative complications and uterine rupture, making this group a high-risk category that requires special attention in efforts to reduce maternal and perinatal morbidity and mortality rates. Method. This was an analytical observational study using a cross-sectional design based on medical record data. The study population included all mothers who delivered via cesarean section at the Regional General Hospital of Kendari during 2023–2024. A total of 245 samples were selected using purposive sampling. Data were analyzed using the chi-square test, with a significance level set at > 0.05. Results. The study found 148 cases (60.4%) were repeat cesarean sections and 97 cases (39.6%) were primary cesarean sections. The analysis showed significant associations between maternal age (p=0.000) and PROM (p=0.000) with repeat CS. There was no significant association between cervical dilatation (p=0.172) and repeat CS. Conclusion. This study demonstrates significant associations between maternal age and premature rupture of membranes with the incidence of repeat cesarean section at Kendari General Hospital during 2023–2024.
subject: Articles
  topic: section
subject: maternal age
  topic: keywords
subject: cervical dilatation
  topic: keywords
subject: premature rupture of membrane
  topic: keywords
subject: repeat cesarean section
  topic: keywords
creator: Wa Ode Nurhiqmah Basri Wa Ode Nurhiqmah Basri
creator: Juminten Saimin
creator: Livy Leonard Lieswan
rights: Copyright (c) 2025 Lombok Medical Journal
date: 2025-10-02
publication date: 2025-10-02
starting page: 104
ending page: 108
doi: 10.29303/lmj.v4i3.7920

Oral Cancer and Reconstruction: A Serial Case Report
type: item
description: Introduction : The head and neck cancer are sixth most common cancers worldwide with cancer of oral cavity. The basic treatment modality for the carcinoma of oral cavity has been surgery and the large defects resulting from the ablation of the tumors require reconstruction. Reconstruction after wide excision of oral cancer challenge in itself, because it requires an appropriate method of reconstruction, in accordance with oncology rules and while maintaining the function . In this case serial, several methods of reconstruction from oral cancer are discussed. Case Report : We report 3 cases of patients female aged 48-71 years with complaints of lumps on the tongue. Patients with risk factors poor oral hygiene. On physical examination, cervical lymph node enlargement was found at levels I-IV. All patients underwent a CT scan of the head and neck. On histopathological examination, squamous cell carcinoma was found, the stage of oral cancer in this case series was stage I-III. The surgery was performed with a combined mandibular and neck dissection operation (Commando) with LD flap, and SCM flap. The patient is then treated in the intensive care unit for 1-2 days, then treated in the usual room and discharged on the 5-7th day of treatment without complications Discussion : Although there is increasing use of microvascular free flap in this era, however, conventional flap like LD and SCM still remains very reliable and versatile myocutaneous flap for primary as well as secondary reconstruction, In head and neck reconstruction, LD and SCM flap is used extensively due to its proven reliability and multipurpose nature . The main advantage of LD and SCM flap is that it can be used in a very wide range of defects in the head and neck region including the maxilla, neck as well as tempero-orbital area. Like the other myocutaneous flap, LD and SCM is harvested by single stage reconstructive procedure and does not require any flap delay or release. The morbidity of the donor site…
subject: Articles
  topic: section
subject: Head and neck cancer
  topic: keywords
subject: head and neck reconstruction
  topic: keywords
subject: oral cancer
  topic: keywords
creator: Lalu Fahril Ilham
creator: Made Agus Suanjaya
creator: Lalu Fauzan Adi Yuliansyah
rights: Copyright (c) 2025 Lombok Medical Journal
date: 2025-10-02
publication date: 2025-10-02
starting page: 117
ending page: 120
doi: 10.29303/lmj.v4i3.7894

Diagnosis dan Tatalaksana Postherpetic Neuralgia
type: item
description: Postherpetic Neuralgia (PHN) is a chronic pain condition that occurs after the resolution of Herpes zoster, significantly affecting patients’ quality of life. PHN is characterized by spontaneous pain, hyperalgesia, allodynia, and paresthesia. Major risk factors include advanced age, severity of rash, and ophthalmic involvement. The pathophysiology involves reactivation of the varicella-zoster virus (VZV), leading to nerve inflammation and peripheral sensitization. Management of PHN includes analgesics, antiepileptic drugs (pregabalin, gabapentin), antidepressants, and topical therapies such as capsaicin and lidocaine. Prevention can be achieved through zoster vaccination. Combination therapy is often required to optimize treatment outcomes in PHN.
subject: Articles
  topic: section
subject: Postherpetic
  topic: keywords
subject: Neuralgia
  topic: keywords
subject: Herpes zoster
  topic: keywords
subject: Chronic Pain
  topic: keywords
subject: Treatmen
  topic: keywords
subject: Vaccination
  topic: keywords
creator: Ali Ramzi
creator: Fatimah Firza
rights: Copyright (c) 2025 Lombok Medical Journal
date: 2025-10-02
publication date: 2025-10-02
starting page: 97
ending page: 103
doi: 10.29303/lmj.v4i3.7505

Mengenal Human Metha Pneumo Virus (HMPV) yang merebak di beberapa Negara
type: item
description: Abstract Human Meta Pneumo Virus (HMPV) is a single strain virus identifies as a cause of upper airway infection. Recently, several new cases reported in some countries, including Indonesia. After the virus infected the epithelial cell, it will replicated exponentially and spreading to adjacent cells. As a result, it will break the tissue and lead to inflammation. In patient with immunocompromised, HMPV infection will continued to pneumonia and other serious complication. Therefore, it is necessary to inform this virus characteristics to the health care professionals to allow them can tackle the disease accurately. Finally, it could limiting the potency of the occurrence of epidemic in population.
subject: Articles
  topic: section
subject: HMPV
  topic: keywords
subject: upper airway infection
  topic: keywords
subject: epidemy
  topic: keywords
creator: Hamsu Kadriyan
rights: Copyright (c) 2025 Lombok Medical Journal
date: 2025-05-31
publication date: 2025-05-31
starting page: 75
ending page: 77
doi: 10.29303/lmj.v4i2.6838

Klasifikasi dan Faktor Risiko Ruptur Aneurisma Intrakranial; Sebuah Tinjauan Pustaka
type: item
description: Abstract: Intracranial aneurysms are cerebrovascular abnormalities resulting from structural weakness in the arterial wall, which may rupture and lead to aneurysmal subarachnoid hemorrhage (aSAH), a condition associated with high morbidity and mortality rates. The formation of aneurysms is a multifactorial process that culminates in degenerative changes within the vessel wall. Aneurysms are classified based on morphology (saccular, fusiform, dissecting), size (ranging from small to giant), and anatomical location. The mechanism underlying aneurysm rupture can be explained by the concept of wall shear stress (WSS) in cerebral vessels. Other critical risk factors for aneurysm rupture include aneurysm size and location. A thorough understanding of the classification and risk factors for aneurysm rupture is essential to improve preventive management strategies in clinical practice.
subject: Articles
  topic: section
subject: intracranial aneurysm
  topic: keywords
subject: rupture
  topic: keywords
subject: aSAH
  topic: keywords
subject: risk factors
  topic: keywords
subject: rebleeding
  topic: keywords
subject: pathophysiology
  topic: keywords
creator: Baiq Holisatul Ismiana
creator: Setyawati Asih Putri
creator: Raditya Rachman Landapa
creator: Lusye Diana Jacob
rights: Copyright (c) 2025 Lombok Medical Journal
date: 2025-10-02
publication date: 2025-10-02
starting page: 109
ending page: 116
doi: 10.29303/lmj.v4i3.7014

Analisis Kelayakan Integrasi Otopsi Virtual dalam Sistem Visum et Repertum di Indonesia: Perspektif Medis, Yuridis, dan Teknologis
type: item
description: Otopsi virtual (virtopsi) menawarkan alternatif non-invasif untuk otopsi konvensional dengan memanfaatkan teknik pencitraan radiologi. Integrasinya ke dalam sistem visum et repertum Indonesia, yang berfungsi sebagai kerangka pelaporan mediko-hukum utama, menjanjikan tetapi tertantang oleh keterbatasan hukum, pendidikan, dan infrastruktur. Makalah ini mengulas kelayakan dan prospektus penerapan virtopsi di Indonesia dari empat perspektif—medis, hukum, pendidikan, dan teknologi—yang didukung oleh studi kasus internasional. Penelitian ini mengkaji integrasi virtopsi ke dalam pendidikan kedokteran dan praktik forensik, menganalisis kelayakan, manfaat, dan kendalanya dalam konteks mediko-hukum Indonesia. Penulis berpendapat bahwa meskipun virtopsi, yang memanfaatkan teknik pencitraan canggih seperti CT dan MRI, menawarkan alternatif minimal invasif dan meningkatkan presisi diagnostik dan penerimaan budaya, reformasi regulasi, program pelatihan, dan investasi dalam infrastruktur pencitraan sangat penting untuk keberhasilan penerapannya.
subject: Articles
  topic: section
subject: virtual autopsy
  topic: keywords
subject: visum et repertum
  topic: keywords
subject: forensic medicine
  topic: keywords
subject: medico-legal imaging
  topic: keywords
subject: indonesia
  topic: keywords
creator: Danesh Hadyljinan Utomo
rights: Copyright (c) 2025 Lombok Medical Journal
date: 2025-10-02
publication date: 2025-10-02
starting page: 129
ending page: 134
doi: 10.29303/lmj.v4i3.6997

Additionally, the Author Examines the Management, Prognosis, and Complications Associated with RBBB.
type: item
description: Right Bundle Branch Block (RBBB) is an abnormality in the physiological electrical conduction system of the heart, resulting from a blockade of the right bundle branch. The global incidence of RBBB is estimated to be approximately 0.8% annually. Typically, RBBB is considered a mild finding that does not increase the risk in otherwise healthy individuals without structural heart disease. However, RBBB may also be indicative of myocardial disease and has been identified as a predictor of mortality in certain populations. This literature review aims to summarize the pathophysiology and clinical approach to RBBB, with a particular focus on echocardiography (ECG) examinations, based on literature sourced from PubMed, Google Scholar, and additional manual searches conducted between 2016 and 2021. Additionally, the author examines the management, prognosis, and complications associated with RBBB.
subject: Articles
  topic: section
subject: Right Bundle Branch Block
  topic: keywords
subject: pathophysiology
  topic: keywords
subject: diagnosis
  topic: keywords
subject: clinical approach
  topic: keywords
creator: Lalu Fahril Ilham
creator: Pendy Wastu Haribowo
rights: Copyright (c) 2025 Lombok Medical Journal
date: 2025-05-31
publication date: 2025-05-31
starting page: 70
ending page: 74
doi: 10.29303/lmj.v4i2.6636

A Case Report Disfonia et causa Nodul Vocal Cords Bilateral
type: item
description: Dysphonia is a commonly used term for any voice disorder resulting from abnormalities in the organs of phonation, especially the larynx, whether organic or functional. Vocal cord nodules or often known as “singer's nodes”, “screamer's nodes” or “teacher's nodes” are one of the most common causes of dysphonia in children. It is known that vocal cord nodules are a condition where there is swelling of the bilateral vocal cords of varying sizes, which can generally be found in the center of the vocal cord membrane. These nodules are characterized by epithelial thickening with different levels of inflammatory reaction in the superficial layer of the lamina propia. In this case report will discusses abouta 49-year-old woman who came to the ENT clinic of the NTB Provincial Hospital with a chief complaint of hoarseness. Furthermore, from the anamnesis, physical examination and supporting examination, the patient was diagnosed with dysphonia ec bilateral vocal cord nodules.
subject: Articles
  topic: section
subject: Dysphonia
  topic: keywords
subject: Nodule
  topic: keywords
subject: Vocal cords
  topic: keywords
subject: Hoarseness
  topic: keywords
creator: Siti Jaisy Millah Hadaina
creator: Dita Mutia
creator: Nafatasya Ayu Rahmansyah
creator: Latifa Intan Rahma
creator: Haldy Dwi Febrian
rights: Copyright (c) 2025 Lombok Medical Journal
date: 2025-05-31
publication date: 2025-05-31
starting page: 65
ending page: 69
doi: 10.29303/lmj.v4i2.6350